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Endocrine Abstracts

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ea0029p500 | Diabetes | ICEECE2012

Evidence that abscissic acid participates in the response to hyperglycemia in humans

Ameri P. , Bruzzone S. , Briatore L. , Mannino E. , Basile G. , Ponta M. , Grozio A. , Magnone M. , Guida L. , Scarfi S. , Salis A. , Damonte G. , Sturla L. , Nencioni A. , Fenoglio D. , Fiory F. , Miele C. , Beguinot F. , Maggi D. , Cordera R. , Murialdo G. , De Flora A. , Zocchi E.

Abscissic acid (ABA) is a hormone best known for its role in plants. We previously showed that it is released by pancreatic beta-cells upon glucose stimulation, and autocrinally enhances insulin secretion.Here we additionally report that ABA promotes glucose uptake by rat L6 myoblasts and murine 3T3-L1 cells differentiated to adipocytes, at least partly by inducing GLUT-4 translocation to the plasma membrane.To determine whether AB...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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